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OLS Field Name OLS Field Data
Main Title Mutagenic Screening of Three Dyes for Marker Grenades in the Salmonella Reversion Assay and the L5178Y/TK+/-Mouse Lymphoma Assay.
Author Moore, M. M. ; Claxton, L. ; Houk, V. ; Nelson, G. M. ; Brock, K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher Dec 88
Year Published 1988
Report Number EPA/600/1-88/007;
Stock Number PB89-131346
Additional Subjects Mutagenicity tests ; Dyes ; Grenades ; Toxicity ; Salmonella typhimurium ; Lymphoma ; Cells(Biology) ; Solvent Red 1 ; Disperse Blue 3 ; Disperse Red 11 ; Occupational safety and health ; Ethene/bromo
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-131346 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 144p
Abstract
Dyes are used by the military in M18 marker signaling grenades. The U.S. Army is concerned with evaluating any potential health hazards that might result from personal contact with the dyes in the industrial setting. Three dyes (Solvent Red 1, Disperse Blue 3, and Disperse Red 11) were tested for mutagenicity in the Salmonella reversion assay and the L5178Y/TK(sup +/-) mouse lymphoma assay. The in vitro assays were performed both with and without exogenous activation provided by Aroclor induced rat liver S-9. In the Salmonella assay, Solvent Red 1 was positive with S-9 activation in strain TA100 and negative to questionably positive in the other strains and activation conditions. Disperse Blue 3 was positive with S-9 activation in strain TA1537 and negative to questionably positive under the other test conditions. Disperse Red 11 was positive with S-9 activation in strain TA102, but negative to weakly positive with the other strains and activation conditions. Both Disperse Blue 3 and Disperse Red 11 were positive both with and without S-9 activation in the mouse lymphoma assay. Solvent Red 1 could not be tested without activation. With S-9 activation, it was weakly positive.