Record Display for the EPA National Library Catalog

RECORD NUMBER: 32 OF 217

OLS Field Name OLS Field Data
Main Title Comparative Ability of Various PCBs, PCDFs, and TCDD to Induce Cytochrome P450 1A1 and 1A2 Activity Following 4 Weeks of Treatment (Short Communication).
Author De Vito, M. J. ; Maier, W. E. ; Diliberto, J. J. ; Birnbaum, L. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/099;
Stock Number PB93-175685
Additional Subjects Chlorine organic compounds ; Toxicity ; Public health ; Tests ; Exposure ; Risk assessment ; Mice ; Biphenyl ; Oxygen heterocyclic compounds ; Industrial wastes ; Enzymes ; Reduction ; Reprints ; Toxic equivalency factors ; Polychlorinated biphenyls ; Biphenyl/chloro ; Dioxin/tetrachloro-dibenzo ; Chloronated dibenzofurans ; Cytocrome P-450
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-175685 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/23/1993
Collation 8p
Abstract
The toxic equivalency factors (TEF) have been proposed for dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls (PCBs). The proposed TEFs, which are presently being evaluated in the authors' laboratory are currently used to estimate the potential health risk associated with exposure to complex mixtures containing these chemicals. Hepatic cytochrome P-450 1A1 and 1A2 activities were determined for all chemicals tested and compared to those from TCDD treated mice. These initial studies indicate that the interim TEFs for the dibenzofurans adequately predict the relative induction potency for these compounds. However, the TEFs proposed for the 'dioxin-like' PCBs overestimate the potency of these compounds by factors of 10-10,000. The present study indicates that more experimental data is required before TEFs for PCBs are used in regulatory decision making. (Copyright (c) 1993 by the Society of Toxicology.)