Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 9

OLS Field Name OLS Field Data
Main Title Hormonal Influences on DDT Metabolism in the White Rat.
Author Durham, William F. ; Cueto, Jr., Cipriano ; Hayes, Jr., Wayland J. ;
CORP Author Communicable Disease Center, Savannah, Ga.
Year Published 1956
Stock Number PB-278 087
Additional Subjects Hormones ; DDT ; Toxicology ; Pesticides ; Insecticides ; Esters ; Oxygen organic compounds ; Metabolism ; Rats ; Absorption(Biology) ; Sex ; Males ; Females ; Fats ; Testosterone ; Bioassay ; Laboratory animals ; Experimental data ; Liver ; Body weight ; Reprints ; Metabolites ; DDE insecticide ; Diethylstilbestrol ; Pesticide residues ; Toxic substances ; Propionic acid/(testosterone-ester) ; Bioaccumulation
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-278 087 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 5p
Abstract
The influence of diethylstilbestrol (DES) and testerone propionate (TP) on the storage of DDT and its metabolite, DDE, was studied in normal and in gonadectomized rats. As expected, TP dosage increased the growth of female rats while DES administration inhibited the growth of males. Both hormones inhibited gonadal growth. Rats that received either DDT or hormone showed an increased liver weight/body weight ratio as compared to control animals. This effect was more marked in males than in females. DES increased DDT and DDE storage in fat in the male while TP decreased these values in the female. Similar effects of hormone dosage were noted on the ratio of DDE to total DDT-derived material stored in fat.