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RECORD NUMBER: 7 OF 146

OLS Field Name OLS Field Data
Main Title Altered Function and Histology in Guinea Pigs after Inhalation of Diesel Exhaust.
Author Wiester, M. J. ; Iltis, R. ; Moore, W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-81-030;
Stock Number PB81-184764
Additional Subjects Exhaust emissions ; Toxicology ; Air pollution ; Exhaust gases ; Guinea pigs ; Laboratory animals ; Histology ; Exposure ; Reprints ; Diesel engine exhaust ; Air pollution effects(Animals) ; Toxic substances
Holdings
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Status
NTIS  PB81-184764 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 15p
Abstract
Health effects of inhaled diesel engine exhaust were evaluated in infant guinea pigs following 4 and 8 weeks of exposure. Animals were exposed to 1 part exhaust diluted by 13 parts clean air for 20 hr/day, 7 days/week. Lung function, electrocardiogram, growth rate, and histopathology were assessed following exposure. After 4 weeks, animals exposed to irradiated exhaust, showed a 35% increase in pulmonary air flow resistance, and a small but significant decrease in heart rate. Necropsy, after 8 weeks, showed exhaust exposed animals to have black discoloration of the lungs and increased lung to body weight ratios. Microscopic examination of the lungs from these animals revealed black particulate material in the cytoplasm of alveolar macrophages and in draining lymph nodes.