Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Pulmonary Function and Pathology in Cats Exposed 28 Days to Diesel Exhaust.
Author Pepelko, William E. ; Mattox, Joan K. ; Yang, You Yen ; Moore, Jr, Wellington ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1980
Report Number EPA-600/J-80-180;
Stock Number PB81-196578
Additional Subjects Toxicology ; Exhaust gases ; Pathology ; Respiratory system ; Cats ; Exposure ; Laboratory animals ; Concentration(Composition) ; Lung ; Reprints ; Diesel engine exhaust ; Toxic substances ; Air pollution effects(Animals) ; NTISEPAORD
Library Call Number Additional Info Location Last
NTIS  PB81-196578 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Young adult male cats were exposed 28 days, 20 hours per day, to a 1:14 dilution of diesel exhaust emissions. Following termination of exposure, the following pulmonary function measurements were carried out: lung volumes, maximum expiratory flow rates (MEF), MEF at 50%, 25% and 10% of vital capacity (VC): forced expiratory volume (FEV) after 0.2, 0.3 and 0.4 seconds, dynamic compliance, resistance and helium washout at 25, 50, 75 and 100 breaths per minute. The only significant functional change was a decrease in MEF at 10% of VC (P= .02). The lungs of the exposed cats appeared charcoal grey with frequent focal black spots visible for the pleural surface. Pathologic changes in the exposed cats included a predominantly peribronchiolar localization of black-pigmented macrophages within the alveoli producing a focal pneumonitis or alveolitis. In general, evidence of serious lung damage was not observed following the 28-day exposure period.