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RECORD NUMBER: 101 OF 146

OLS Field Name OLS Field Data
Main Title Metabolism, Mutagenicity, and Activation of 1-Nitropyrene In vivo and In vitro.
Author Ball, L. M. ; King, L. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ., Chapel Hill. Dept. of Environmental Sciences and Engineering.
Year Published 1985
Report Number EPA/600/J-85/191;
Stock Number PB86-117702
Additional Subjects In vivo analysis ; In vitro analysis ; Air pollution ; Mutagens ; Particles ; Toxicology ; Laboratory animals ; Rats ; Parenteral infusions ; Bioassay ; Aromatic polycyclic hydrocarbons ; Ingestion(Biology) ; Dosage ; Isotopic labeling ; Exhaust emissions ; Reprints ; Pyrene/nitro ; Air pollution effects(Animals) ; Air pollution detection ; Diesel engine exhaust
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-117702 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
The genotoxic air pollutant 1-nitropyrene (NP) labelled with 14C was administered to rats as the pure compound (6 micromole) by intraperitoneal injection, and vapor-phase-coated onto diesel particles (380 ppm 5 mg/rat) by oral and intratracheal instillation (i.t.). In all three cases well over 50% of the 14C label was recovered within 24 H, 20-30% in the urine and 40-60% in the faeces. Following i.t., most of the particles were recovered in the lung, trachea and oesophageal cavities; after oral dosing particles were mainly in the faeces. The similarity in elimination kinetics and metabolite profile following such diverse doses and routes of administration indicates that NP is readily released from diesel particles both in the lung and in the gastrointestinal tract, and that the dose range used (10 microgram to 10 mg/kg body weight) is either well above or well below the level needed to saturate metabolism and excretory mechanisms in the rat. Accumulations of 14C remained in the lung and gastro-intestinal tract 24 h after i.t.; these organs might therefore be particularly vulnerable to possible damage by NP.