Record Display for the EPA National Library Catalog

RECORD NUMBER: 50 OF 187

OLS Field Name OLS Field Data
Main Title Effect of Repeated Administration of Phenobarbital on the Metabolism of Dieldrin.
Author Cueto, Jr., Cipriano ; Hayes, Jr., Wayland J. ;
CORP Author National Communicable Disease Center, Atlanta, Ga.
Year Published 1967
Stock Number PB-280 091
Additional Subjects Pesticides ; Insecticides ; Dieldrin ; Phenobarbital ; Toxicology ; Metabolism ; Chlorine organic compounds ; Chlorohydrocarbons ; Barbiturates ; Drugs ; Detoxification ; Tissues(Biology) ; Liver ; Fats ; Absorption(Biology) ; Reprints ; Toxic substances ; Adipose tissue ; Bioaccumulation
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 091 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 5p
Abstract
The data presented in this paper show that phenobarbital decreases the storage level of dieldrin in fat without any appreciable effect on the concentration of the pesticide in liver. The decreased level in fat may be explained on the basis of an increased liver microsomal enzyme activity. As the metabolic turnover in the liver increases, more of the metabolized pesticide is excreted and less dieldrin is channeled to the fat depots. The rate of liver metabolism of dieldrin does not appear to be a limiting factor in the storage of dieldrin in the liver itself. It is safe to assume that, in conrast to fat, the presence of dieldrin in the liver is more dependent upon dosage and fatty content than upon rate of biotransformation.