Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Impact of pharmacokinetics on the risk assessment of dichloromethane
Author Blancato, Jerry N. ; Rhomberg, L.
Other Authors
Author Title of a Work
Rhomberg, Lorenz.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment,
Year Published 1988
Report Number EPA/600/D-88/219
Stock Number PB89-173249
Subjects Dichloromethane--Toxicology ; Carcinogenicity testing
Additional Subjects Physiology ; Chloromethanes ; Bioassay ; Environmental surveys ; Exposure ; Laboratory animals ; Humans ; In vitro analysis ; Metabolism ; Pharmacokinetics ; Risk assessment ; Methane/dichloro ; Dose response relationships
Library Call Number Additional Info Location Last
NTIS  PB89-173249 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 8 p. : ill. ; 28 cm.
The paper recapitulates the means by which a physiologically based risk assessment for dichloromethane (DCM, methylene chloride) evolved. Two somewhat different physiologically based pharmacokinetic (PBPK) models had been published by Angelo et al. in 1984 and Andersen et al. in 1987. The paper discusses the rationale for the selection and implementation of a PBPK model for purposes of estimating the delivered or effective dose. Also discussed is the rationale used for selecting the scaling method for estimating the equivalency of delivered dose between test species and humans.
"EPA/600/D-88-219." "May 1988." "PB89-173249."