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RECORD NUMBER: 2 OF 24

OLS Field Name OLS Field Data
Main Title Acute and Subchronic Toxicity in Rats of Trans-1,2-Dichloroethylene in Drinking Water (Journal Version).
Author Hayes, J. R. ; Condie, L. W. ; Egle, J. L. ; Borzelleca, J. F. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/389;
Stock Number PB89-101117
Additional Subjects Toxicity ; Toxic substances ; Potable water ; Dichloroethylenes ; Histology ; Organ weight ; Laboratory animals ; Chlorine organic compounds ; Exposure ; Reprints ; Health effects ; Ethene/trans-dichloro ; CAS 156-60-5 ; Risk assessment
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB89-101117 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 10p
Abstract
Trans-1,2 dichloroethylene has been identified in drinking water at a concentration of approximately 1.0 micrograms/liter. The study provides data on the effects of trans-1,2 dichloroethylene in drinking solutions. The acute oral LD50 in male and female Charles River rats was found to be 7902 mg/kg for males and 9939 mg/kg for females. Male and female Charles River rats receive theoretical daily doses of 500, 1500 and 3000 mg/kg b.w./day for 90 consecutive days. There were no compound-related deaths. There were no consistently significant dose-related effects on any of the hematological, serological or urinary parameters evaluated. There were dose-dependent increases in the liver and kidney weights and ratios. There were no compound-related gross or histological effects. These data suggest that exposure of humans to reported levels of trans-1,2 dichloroethylene does not constitute a serious health hazard.