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RECORD NUMBER: 4 OF 4

OLS Field Name OLS Field Data
Main Title Metabolism of Dibenzo-p-Dioxin and Chlorinated Dibenzo-p-Dioxins by a Beijerinckia Species.
Author Klecka, Gary M. ; Gibson, David T. ;
CORP Author Texas Univ. at Austin. Dept. of Microbiology.;Environmental Research Lab., Gulf Breeze, FL.
Year Published 1980
Report Number EPA-R-804525; EPA-600/J-80-131 ; ERL.GB-0091
Stock Number PB81-129488
Additional Subjects Metabolism ; Bacteria ; Toxicology ; Chlorine organic compounds ; Oxygen organic compounds ; Reprints ; Dibenzodioxins ; Beijerinckia ; Toxic substances ; Dibenzodioxin/chloro ; Dibenzodioxin/dihydroxy-dihydro ; Dihydrodiols ; Dibenzodioxin/dihydroxy
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB81-129488 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
Whole cells of the parent strain of Beijerinckia, grown with succinate and biphenyl, oxidized dibenzo-p-dioxin and several chlorinated dioxins. The rate of oxidation of the chlorinated dibenzo-p-dioxons decreased with an increasing degree of chlorine substitution. A mutant strain (B8/36) of Beijerinckia oxidized dibenzo-p-dioxin to cis-1,2-dihydroxy-1,2-dihydrodibenzo-p-dioxin. The mutant organism also oxidized two monochlorinated dibenzo-p-dioxins to cis-dihydrodiols. No metabolites were detected from two dichlorinated dibenzo-p-dioxins. Growth of the parent strain of Beijerinckia was inhibited after 4 hr when 0.05% dibenzo-p-dioxin was present in the culture medium. Resting cell suspensions of the parent organism, previously grown with succinate and biphenyl, oxidized dibenzo-p-dioxin to a compound identified as 1,2-dihydroxydibenzo-p-dioxin. Further degradation of this metabolite was not detected, as the compound was found to be a potent mixed-type inhibitor of two ring-fission oxygenases present in this organism.