Main Title |
Assessment of clinical procedures to evaluate liver intoxication in fish / |
Author |
Gingerich, William H., ;
Weber, Lavern J.
|
Other Authors |
|
CORP Author |
Oregon State Univ., Corvallis. Dept. of Fisheries and Wildlife.;Environmental Research Lab., Duluth, MN. |
Publisher |
Environmental Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
1979 |
Report Number |
EPA-600/3-79-088; EPA-R-803090 |
Stock Number |
PB80-101595 |
OCLC Number |
05786694 |
Subjects |
Fishes--Effect of water pollution on--United States ;
Rainbow trout ;
Liver--Diseases ;
Oncorhynchus mykiss ;
Liver--Diseases--Diagnosis ;
Liver function tests ;
Rainbow trout--Diseases
|
Additional Subjects |
Toxicology ;
Liver ;
Fishes ;
Evaluation ;
Assessments ;
Procedures ;
Enzymes ;
Biochemistry ;
Physiology ;
Exposure ;
Toxicity ;
Rainbow trout ;
Toxic substances
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
SH174.G56 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJBD |
EPA 600-3-79-088 |
|
Headquarters Library/Washington,DC |
04/01/2014 |
ELBD ARCHIVE |
EPA 600-3-79-088 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-3-79-088 |
|
AWBERC Library/Cincinnati,OH |
04/10/1998 |
ELDD |
EPA 600-3-79-088 |
|
CCTE/GLTED Library/Duluth,MN |
05/24/2021 |
ESAD |
EPA 600-3-79-088 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB80-101595 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
xii, 106 pages : illustrations ; 28 cm. |
Abstract |
Procedures were developed to clinically evaluate liver damage and liver function in rainbow trout following either acute intraperitoneal (i.p.) treatment or subacute bath exposure to selected mammalian hepatotoxic agents. Elevations in serum of liver specific enzymes such as aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and alkaline phosphatase (AP) were investigated as potential indicators of hepatocellular damage. An exogenous test of liver function, plasma clearance of the organic anion sulfobromophthalein (BSP), also was investigated as a potentially useful test of overall liver function in the trout. The application of clinical tests to diagnose liver dysfunction in fishes following their exposure to environmental toxicants may be practical in controlled laboratory facilities. Despite the considerable variation that exists between groups of fish, significant differences could be demonstrated between control and treated fish. Variation among groups of fish make intergroup comparison of the field populations increasingly difficult by these methods. Therefore, the use of such techniques should be employed to evaluate liver toxicity under precisely controlled laboratory studies. Their application to field studies does not seem advisable. |
Notes |
"Physiological Effects of Pollution Section, Environmental Research Laboratory." "August 1979." Bibliographies: pages 94-105. Grant no. |