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RECORD NUMBER: 9 OF 10

OLS Field Name OLS Field Data
Main Title Subchronic (4-week) Dietary Oral Toxicity Study of Di(2-ethylhexyl)phthalate in B6c3f1 Mice (Final Report) with Attachments and Cover Letter Dated 04/03/1992.
CORP Author Hazleton Washington; Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 86-920000874
Stock Number OTS0535432
Additional Subjects Toxicology ; Health effects ; Di(2-ethylhexyl)phthalate (117-81-7) ; Subchronic Toxicity ; Mammals ; Mice ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 117-81-7
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NTIS  OTS0535432 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 289p
Abstract
Bis(2-ethylhexyl) phthalate (CAS No. 117-81-7) was evaluated for subchronic toxicity. The test substance was administered in the diet ad libitum at 0, 1,000, 5,000, 10,000, and 25,000 ppm to rats (10/sex/group) for 4 weeks. In the highest dose group, there were 7/20 deaths, and clinical signs in this group included hunched posture, thin appearance, hypoactivity, tremors, urine stains, dyspnea, and rough coat. Body weights were decreased in the two highest groups. Animals from the 25,000 ppm group had significantly lower mean erythrocyte counts, hemoglobin, and hematocrit values as compared to controls. At 5,000 ppm and higher, there were kidney lesions, gross hepatic lesions, hepatocellular hypertrophy, and hepatic necrosis. Absolute and relative testes weights were markedly lower in the 25,000 ppm group and absolute and relative liver weights were markedly higher in the 10,000 and 25,000 ppm groups as compared to controls. Testicular atrophy was noted in all 25,000 ppm males. Thymic atrophy of both sexes and the absence of corpora lutea in females were also noted in the 25,000 ppm group. The NOEL of this study was 1,000 ppm.