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RECORD NUMBER: 8 OF 10

OLS Field Name OLS Field Data
Main Title Subchronic (13-week) Dietary Oral Toxicity Study of Di(2-ethylhexyl)phthalate in Fischer 344 Rats (Final Report) W-attachments and Letter dated 040392 (missing Pages 304 to 386).
CORP Author Hazleton Washington; Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 86-920000875
Stock Number OTS0535433
Additional Subjects Toxicology ; Health effects ; Di(2-ethylhexyl)phthalate (117-81-7) ; Subchronic Toxicity ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 117-81-7
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NTIS  OTS0535433 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 443p
Abstract
Bis(2-ethylhexyl) phthalate (CAS No. 117-81-7) was evaluated for subchronic toxicity. The test substance was administered in the diet ad libitum to rats (10/sex/group) at doses of 0, 1,000, 4,000, 12,500, and 25,000 ppm for 13 weeks. There were no deaths. Relative to controls, males in the 1,000 ppm group had significantly increased liver weight and females had significantly increased kidney weights. At 4,000 ppm, there were low red cell counts (males), slight hepatocellular enlargement (males), increased liver weights (males and females), increased blood urea nitrogen levels (males), and increased kidney weights (males and females). Rats treated with 12,500 ppm had urine stains, mild anemia, kidney and liver changes (increase in weight and hepatocellular enlargement as compared to controls), and low body weight (females only). Low body weight gain, urine stains, mild anemia and microscopic changes of the pituitary gland, adrenal cortex, kidney and liver (increase in weight and hepatocellular enlargement as compared to controls), and testes/epididymides (decrease in weight and increase in atrophy and aspermia as compared to controls) were noted in the 25,000 ppm group.