Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 10

OLS Field Name OLS Field Data
Main Title Inhibition of Gap-Junctional Intercellular Communication between Chinese Hamster Lung Fibroblasts by Di (2-Ethylhexyl) Phthalate (DEHP) and Trisodium Nitrilotriacetate Monohydrate (NTA).
Author Malcolm, A. R. ; Mills., L. J. ;
CORP Author Environmental Research Lab., Narragansett, RI. ;Science Applications International Corp., Narragansett, RI.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/179 ;ERLN-795;
Stock Number PB90-140336
Additional Subjects Lung ; Toxicology ; Carcinogens ; Inhibitors ; Reprints ; Intercellular junctions ; Di(2-ethylhexyl)phthalate ; Ethylhexyl ; Trisodium nitrilotriacetate monohydrate ; Chinese hamsters ; Fibroblasts
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-140336 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/15/1990
Collation 11p
Abstract
Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals. (Copyright (c) 1989 Princeton Scientific Publishing Co.)