Record Display for the EPA National Library Catalog

RECORD NUMBER: 27 OF 308

OLS Field Name OLS Field Data
Main Title Acute Toxicity Studies in Rabbits and Rats with Attachments, Cover Sheet and Letter dated 07/19/1978.
CORP Author Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1978
Report Number 8EHQ-0878-0229
Stock Number OTS0200545
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Benzoflex s-552 ; Laboratory animals ; Primary eye irritation ; Mammals ; Rabbits ; Dermal ; Primary dermal irritation ; Acute toxicity ; Rats ; Gavage ; CAS No 4196-86-5
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NTIS  OTS0200545 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 04/28/2010
Collation 79p
Abstract
A primary eye irritation study in New Zealand white rabbits (3/sex/group) in which animals received 100 mg of pentaerythriol tetrabenzoate in the cupped conjunctival sac of the right eye which remained unwashed for 24 hours indicated the test material was mildly irritating (with group average scores of 12.9 or less). A primary skin irritation study with similar groups in which 500 mg of test material was applied under cover to clipped, abraded skin yielded a score of 0.0, indicating the substance is non-irritating under these conditions. Acute dermal toxicity to rabbits was tested by application of 20,000 mg/kg of test material under cover to clipped abraded and unabraded skin and monitored from 24 hours to 14 days. No observable pharmacotoxic signs or dermal irritation were seen. An acute oral toxicity test with Sprague-Dawley rats (5/sex/group) in which test material was administered at 5000 mg/kg by gavage as a suspension in corn oil at a volume of 10 ml/kg led to no mortalities. Hypoactivity was the only observable pharmacotoxic sign. Document includes: USEPA Status Report: Benzoflex S-552 with Attachments and Cover Letter dated 01/22/79.