||Battery of Acute Toxicity Tests with Cover Letter.
||Food and Drug Research Labs., Inc., Conshohocken, PA. ;Rohm and Haas Co., Philadelphia, PA. Research Labs.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||23 Feb 1983
Dermal absorption ;
Oral dosage ;
Eye irritation ;
Respiratory distress ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Six New Zealand albino rabbits, 2 to 3 kg, were closely clipped over the back and sides with an Oster electric clipper. A 0.5 gram portion of the test material was introduced under a 1.5 inch, 12-ply gauze patch placed directly over the test site and held in place with Dermicel tape. The rabbits were wrapped with rubber damming for an exposure period of 4 hours. Slight erythema was observed in 4 animals after 4 hours. All signs of irritation had disappeared in 24 hours. Rohm and Haas Company sample '6-8815, Octylphenol,' when applied to the skin of New Zealand albino rabbits in the quantity of 0.5 ml produced no signs of corrosivity.