Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Acute Toxicity Studies in Rats and Rabbits with Cover Letter.
CORP Author International Research and Development Corp., Mattawan, MI. ;Olin Corp., New Haven, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 24 Nov 1982
Year Published 1982
Report Number 878210870;
Stock Number OTS-0205877
Additional Subjects Toxicity ; Laboratory animals ; Alkylating agents ; Oral dosage ; Rats ; Rabbits ; Dermal absorption ; Eye ; Irritation ; Response(Biology) ; Mortality ; Chemical compounds ; Body weight ; Alkyl epoxides ; Oilin Corporation
Library Call Number Additional Info Location Last
NTIS  OTS-0205877 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/09/2008
Collation 88p
The acute oral LD50 of Olin-35836 in the albino rat was found to be 3160 mg. /kg. Confidence could not be calculated because of the all-or-none response exhibited by the groups of rats administered the test material. Olin-53836 did not produce any evidence of dermal irritation or toxicity in the rabbits to which the test material was applied in dosages as high as 2000 mg. /kg. Instillation of Olin-53836 into the unwashed eyes of albino rabbits produced severe irritation including purulent discharge, pannus and opacity of the cornea. These signs were still in evidence at the end of 7 days of observation. However, those rabbits in which the eyes were irrigated 2 and 4 seconds after instillation of the test material, only slight irritation to the conjunctivae was noted which disappeared within 4 days after treatment.