||Acute Toxicity Studies in Rats and Rabbits with Cover Letter.
||International Research and Development Corp., Mattawan, MI. ;Olin Corp., New Haven, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||24 Nov 1982
Laboratory animals ;
Alkylating agents ;
Oral dosage ;
Dermal absorption ;
Chemical compounds ;
Body weight ;
Alkyl epoxides ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The acute oral LD50 of Olin-35836 in the albino rat was found to be 3160 mg. /kg. Confidence could not be calculated because of the all-or-none response exhibited by the groups of rats administered the test material. Olin-53836 did not produce any evidence of dermal irritation or toxicity in the rabbits to which the test material was applied in dosages as high as 2000 mg. /kg. Instillation of Olin-53836 into the unwashed eyes of albino rabbits produced severe irritation including purulent discharge, pannus and opacity of the cornea. These signs were still in evidence at the end of 7 days of observation. However, those rabbits in which the eyes were irrigated 2 and 4 seconds after instillation of the test material, only slight irritation to the conjunctivae was noted which disappeared within 4 days after treatment.