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RECORD NUMBER: 42 OF 395

OLS Field Name OLS Field Data
Main Title Carcinogen-DNA adducts : introduction, literature summary, and recommendations /
Author Soileau, S. D.
CORP Author Lockheed Engineering and Management Services Co., Inc., Las Vegas, NV.;Environmental Monitoring Systems Lab., Research Triangle Park, NC.
Publisher Environmental Monitoring Systems Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1987
Report Number EPA/600/4-87/005; EPA-68-03-3249
Stock Number PB87-145678
Subjects Carcinogens. ; DNA.
Additional Subjects Carcinogens ; Deoxyribonucleic acids ; Risk ; Biological agents ; Proteins ; DNA ; Environmental monitoring ; Xenobiotics ; Proteins ; Environmental health ; Adducts
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB87-145678 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vi, 126 pages ; 28 cm
Abstract
The report summarizes the literature concerning adducts formed by xenobiotics with DNA and/or protein and discusses their feasibility as a monitoring tool for use in exposure and risk assessment. The report is divided into three segments. The first segment provides an introduction to DNA damage and its relation to carcinogenesis. This segment also discusses available methodology for the measurement of macromolecular (DNA, protein) adducts. The techniques were evaluated according to their sensitivity, selectivity, limitations and future possibilities. The next segment provides a summary of the current literature on the individual chemicals found to form adducts in both man and experimental animals. The information in this segment was also tabulated and is located in the appendix. Finally, the conclusion and recommendation section discusses the overall potential for the use of macromolecular adducts as a measure of dose, given the current technology.
Notes
"January 1987." "PB87-145678." "EPA/600/4-87/005." Includes bibliographical references (p. 100-126) Microfiche. 68-03-3249