Record Display for the EPA National Library Catalog

RECORD NUMBER: 31 OF 395

OLS Field Name OLS Field Data
Main Title Biochemical Effects of Three Chlorinated Phenols in Rat Liver.
Author Kitchin, K. T. ; Brown., J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/522;
Stock Number PB90-232265
Additional Subjects Biochemistry ; Toxicology ; Liver ; Phenols ; Chlorinated hydrocarbons ; Leukocytes ; Rats ; Carcinogens ; Lethal dosage ; Tables(Data) ; Reprints ; Dose-response relationships ; DNA damage ; Cytochrome P-450 ; Ornithine decarboxylase ; Glutathione ; Alanine aminotransferase ; Enzyme induction
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-232265 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 10p
Abstract
The hepatic biochemical effects of four chlorinated oxygen containing environmental contaminants were determined. Two oral doses of 1/5 the LD50 of 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol and 2,3,4,6-tetrachlorophenol were given 21 and 4 hours before sacrifice to adult female rats. Although 2,4,6-trichlorophenol is a carcinogen in lifetime rodent studies, no evidence was found for DNA damage in rat liver or the white cells of rat blood. Similiarly no compound related changes were found in serum alanine aminotransferase, hepatic glutathione or cytochrome P-450 content. A dose of 193 mg/kg/day (slightly over the published rat LD50) of 2,3,4,6-tetrachlorophenol increased 5-fold the activity of hepatic ornithine decarboxylase. As 2,4,6-trichlorophenol did not damage DNA or induce hepatic ornithine decarboxylase (a marker of carcinogenic promotion) in the study, no explanation is apparent why this molecule is a carcinogen in rodent lifetime exposures and structurally related congeners are not. (Copyright (c) 1988 Gordon and Breach, Science Publishers, Inc.)