Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 395

OLS Field Name OLS Field Data
Main Title Application of Biomarkers to Predict Responses of Organisms Exposed to Contaminated Marine Sediments.
Author Jackim, E. ; Pesch, G. G. ; Malcolm, A. R. ; Gardner, G. R. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/114 ;ERLN-870;
Stock Number PB90-264169
Additional Subjects Marine biology ; Toxicity ; Mutations ; Field tests ; Reprints ; Biological markers ; Water pollution effects(Animals) ; Phagocytosis ; Enzyme induction ; Mutagenicity tests ; Carcinogenicity tests ; DNA damage ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-264169 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/03/1990
Collation 12p
Abstract
The use of a short-term cellular subcellular biomarkers strategy is being explored to answer accurately and economically some of these questions about bodies of water, with emphasis on estuaries. According to the biomarker concept, the authors should be able to predict whole-organism responses from subcellular, and tissue indicators. Among the possible biomarkers they are exploring are the following; selected biochemical and immunological changes, including mixed-function oxidase induction, phagocytosis and antibody agglutination; several mutation indicators, such as the Ames test, sister chromatid exchange, DNA unwinding, a Salmonella DNA repair induction test(SOS); and a proposed test for tumor promoters (metabolic cooperation assay (V79/MC). Also planned are studies to detect and identify DNA adducts and micronuclei. The results of these studies will be correlated to histopathologic findings. The final goal of the research is to identify the most appropriate biomarkers to detect environmental problems, determine the sources of these problems, and predict the impact of pollution on humans and other animals. Ultimately the information should be useful in reducing risks to human health and the environment.