Record Display for the EPA National Library Catalog

RECORD NUMBER: 131 OF 395

OLS Field Name OLS Field Data
Main Title Environmental Mutagens and Risk Assessment.
Author Lewtas, J. ; Gallagher, J. E. ; DeMarini, D. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/418;
Stock Number PB91-171736
Additional Subjects Environmental pollutants ; Mutagens ; Risk assessment ; Toxicology Environmental exposure pathways ; Mutagenicity tests ; DNA damage ; DNA repair ; Carcinogenicity tests ; Environmental monitoring ; Pulmonary neoplasm ; Dose-response relationships ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-171736 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 11p
Abstract
Recognition that most human exposures to environmental chemicals occur as complex mixtures has stimulated research and the development of new methods to assess exposure, dosimetry, and genotoxic effects. New genetic and molecular methods are being applied to each aspect of research to develop new methods for the assessment of cancer risk from human exposure to complex mixtures. Short-term genetic bioassay methods utilizing new engineered bacterial strains are being used to assess total human exposure to mutagens in the environment. New DNA adduct methods are being used in exposure-dosimetry studies of complex mixtures in humans and in experimental systems. Finally, new advances in sequencing the genetic mutations induced by environmental mutagens will improve our understanding of the relationship between DNA adducts, DNA damage and repair, mutation induction, and tumor initiation.