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RECORD NUMBER: 29 OF 30

OLS Field Name OLS Field Data
Main Title Significance of DNA Damage and Repair Mechanisms in Health Risk Assessment.
Author Rhomberg, L. ; Dellarco, V. L. ; Farland, W. H. ; Cortesi, R. S. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Oct 89
Year Published 1989
Report Number EPA/600/D-91/041;
Stock Number PB91-176941
Additional Subjects Risk assessment ; DNA damage ; Toxicology ; Health hazards ; DNA repair ; Dose-response relationships ; Extrapolation ; Carcinogens ; Mutagens ; Quantitative analysis ; Species specificity ; Cultured cells ; Pharmacokinetics ; Cytokinetics ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-176941 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1991
Collation 9p
Abstract
Estimations of human risk are generally based on animal studies, and thus require a species-to-species extrapolation. Such data are usually obtained at exposure levels much higher than those ordinarily encountered by humans; consequently, estimates of low-dose risk require a consideration of how the animal dose-response can be extrapolated to lower exposures. Information on mechanisms and rates of DNA repair and on similarities and differences among different cell types and species is important in the development of biologically based extrapolation models for quantitative risk assessment. Such information serves to guide or to provide insight into predicted shapes of dose-response curves at low exposures and how to extrapolate risk across species. The paper will present a conceptual outline for considering how information on DNA damage and repair mechanism may be applicable to the assessment of health risks, particularly those posed by exposure to carcinogens and mutagens.