Record Display for the EPA National Library Catalog

RECORD NUMBER: 45 OF 49

OLS Field Name OLS Field Data
Main Title Subchronic in vivo Cytogenetics Assay in Rats using Nose-Only Inhalation Exposure. Draft Report with Attachments and Cover Letter dated 03/15/90.
CORP Author Microbiological Associates, Bethesda, MD. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 27 Feb 1990
Year Published 1990
Report Number FYI-OTS-0390-0747;
Stock Number OTS-0000747
Additional Subjects Rats ; Inhalation ; Hexane ; Assays ; Bone marrow cells ; Chromosome aberrations ; Subchronic in vivo cytogenetics assay ; Sprague-Dawley rats ; Metaphase cells ; Colcemid treatment
Holdings
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Status
NTIS  OTS-0000747 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 47p
Abstract
Male and female Sprague-Dawley rats were exposed nose-only for six hours per day for five consecutive days to commercial hexane at concentrations of 876, 3249 and 8715 ppm. Bone marrow cells, arrested in metaphase by colcemid treatment, were collected at 6 and 24 hours from the midpoint of the last exposure. Metaphase cells were examined microscopically for chromosome aberrations. No statistically significant increases in percentage of aberrant cells were observed in the commercial hexane-exposed animals, regardless of exposure concentration or bone marrow harvest time. The results of the assay indicate that under the conditions described in this report, commercial hexane did not induce chromosomal aberrations in bone marrow cells of male or female rats following inhalation exposure for five consecutive days.