Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Cytotoxicity of Halogenated Alkanes in Primary Cultures of Rat Hepatocytes from Normal, Partial Hepatectomized, and Preneoplastic/Neoplastic Liver.
Author Chang, L. W. ; Pereira, M. A. ; Klaunig, J. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo.
Year Published 1985
Report Number EPA/600/J-85/219;
Stock Number PB86-121506
Additional Subjects Halogen organic compounds ; Toxicity ; Environmental surveys ; Bioassay ; Biochemistry ; Laboratory animals ; Risk ; Metabolism ; Rats ; Exposure ; Hazardous materials ; Cultures(Biology) ; Chloroform ; Liver neoplasms ; Reprints ; Toxic substances ; Environmental health ; Carcinogenesis ; Ethane/dibromo ; Ethane/dichloro ; Ethane/trichloro
Library Call Number Additional Info Location Last
NTIS  PB86-121506 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Six halogenated hydrocarbons: chloroform, 1,2-dibromoethane (1,2-DBE), 1,1-dichloroethane (1,1-DCE), 1,2-dichloroethane (1,2DCE), 1,1,1-trichloroethane (1,1,1-TCE) and 1,1,2-trichloroethane (1,1,2-TCE) were evaluated for their cytotoxicity in primary cultures of rat hepatocytes isolated from normal, partial hepatectomized and from preneoplastic/neoplastic rat liver. None of the six halogenated alkanes exhibited any difference in their cytotoxicity toward hepatocytes isolated from normal liver or from liver containing preneoplastic/neoplastic lesions induced by either procedure.