Record Display for the EPA National Library Catalog

RECORD NUMBER: 50 OF 210

OLS Field Name OLS Field Data
Main Title Cholinergic Involvement in the Action of Formetanate on Operant Behavior in Rats.
Author Moser, V. C. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Year Published 1987
Report Number EPA/600/J-87/030;
Stock Number PB87-198453
Additional Subjects Carbamates ; Insecticides ; Conditioned responses ; Sense organs ; Rats ; Scopolamine ; Toxicity ; Reprints ; Receptors(Cholinergic) ; Conditioning(Operant) ; Receptors(Muscarinic)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB87-198453 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 6p
Abstract
Formetanate (FMT) is a formamidine acaricide/insecticide with a carbamate moiety in its molecular structure. FMT-induced lethality is reportedly due to inhibition of acetylcholinesterase. Here evidence is reported of the neurochemical basis for the sublethal, behavioral effects of FMT in rats. Injections of scopolamine and methylscopolamine 15 min before FMT blocked the response rate suppression, whereas pretreatment with either mecamylamine or hexamethonium did not. These data suggest that FMT acts as an indirect agonist on central and peripheral muscarinic receptors, by inhibiting acetylcholinesterase, to produce changes in schedule-controlled responding.