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RECORD NUMBER: 38 OF 210

OLS Field Name OLS Field Data
Main Title Bitertanol, a Triazole Fungicide, Increases Operant Responding but Not Motor Activity.
Author Allen, A. R. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-93/400;
Stock Number PB93-236370
Additional Subjects Fungicides ; Motor activity ; Operant conditioning ; Rats ; Graphs(Charts) ; Dose-response relationships ; Reprints ; Bitertanol ; Triadimefon
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-236370 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/22/1993
Collation 8p
Abstract
Several recent reports indicate that triadimefon, a triazole fungicide, has effects on behavior that are similar to those of psychomotor stimulants. For example, triadimefon increases overall fixed-interval (FI) response rate, disrupts FI response patterning, increases motor activity, and produces stereotypies at high doses. The study was designed to determine whether similar behavioral effects on FI performance and motor activity could be produced by another triazole fungicide, bitertanol. The effects of bitertanol (10-300 mg/kg, IP) were determined in rats on performance maintained under a multiple FI 1-min FI 5-min schedule of reinforcement. Intermediate doses of bitertanol increased response rates and disrupted response patterning in both FI components. A second experiment determined the effects of the same doses of bitertanol on motor activity. In contrast to its effects on operant responding, bitertanol did not increase motor activity at any of the doses tested. These findings indicate that the behavioral similarities between bitertanol and triadimefon are limited and that a dissociation exists between bitertanol's effects on operant performance and motor activity. (Copyright (c) 1993 Pergamon Press Ltd.)