Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 45

OLS Field Name OLS Field Data
Main Title Initial Submission: 2-Generation Reproduction Study in Rats with Bis(Tri-N-Butyltin)Oxide with Cover Letter dated 09/29/1992.
CORP Author Bio-Dynamics Research and Development Corp., Eugene, OR.; Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0892-11351
Stock Number OTS0571289
Additional Subjects Toxicology ; Health effects ; Bis(Tri-N-Butyltin)Oxide ; Reproduction ; Fertility effects ; Combined teratogenicity ; Reproductive effects ; Mammals ; Rats ; Oral ; Diet ; CAS No 56-35-9
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NTIS  OTS0571289 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/27/2010
Collation 142p
Abstract
This study, conducted for Schering AG and M & T Chemicals, was designed to evaluate the effects of Bis (tri-n-buty1tin) Oxide (T8TO) on the growth, reproductive performance and fertility of rats through two consecutive generations (FO,F1). Test article was mixed with the granulated diet and administered to male and female CD* rats (30/sex/group) at fixed concentrations of 0.5, 5.0 and 50.0 ppm. Included in this study was an untreated diet control group (30/sex). FO adult generation animals were treated over a 10-week premating treatment period and continued to be exposed to treated diets during the ensuing mating, post-mating (males and unmated females), and gestation/lactation intervals of the Fi litters until sacrificed. Fl pups (two/sex/litter) selected at Day 21 (weaning) became a pool of animals from which the Fl adult generation was selected. These pups which had initiated consumption of the dam's diet during lactation continued to consume diets of these same treatment levels during a post-weaning interval and through a 15-week pre-mating treatment period. F1 animals continued on treatment during the ensuing mating period, post-mating period (males and unmated females) and gestation and lactation intervals of the F2 litters until sacrificed. Litter size, pup weight data and pup sex distribution data were recorded at regular intervals during the 21-day lactation period. Litters were culled to four pups/sex when possible, on Day 4 of lactation. Pups were weaned on Day 21 of lactation.