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RECORD NUMBER: 45 OF 45

OLS Field Name OLS Field Data
Main Title US EPA Status Report: Hexamethylene Diamine with Cover Letter.
CORP Author ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 8EHQ-0590-0979
Stock Number OTS0526381-1
Additional Subjects Toxicology ; Health effects ; Hexamethylene Diamine ; Reproduction/fertility Effects ; Combined Teratogenicity/reproductive Effects ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 124-09-4
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NTIS  OTS0526381-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 20p
Abstract
Hexamethylene diamine (1,6-diaminohexane, CAS No. 124-09-4) was administered in the diet to groups of 52 rats (26 males and 26 females) at doses of 50, 150, and 500 mg/kg/day for two generations. A control group received the basal laboratory diet. The F0 and F1 generations were each mated once to produce F1 and F2 generations. Treatment related changes included reduction in weight in F0 males and F1 males and females and reduced food consumption among F0 and F1 males and females in the high dose group. The high dose group also showed reduced litter size, and decreased pup weight on lactation days 14 and 21 for both generations. No other treatment effects were noted with regard to lactation, female body weights, fertility indices, copulatory interval, gestation length, pup survival or appearance, or testes weight or appearance. The authors conclude that the 150 mg/kg/day level can be considered the dietary 'no effect' level. This EPA status report only includes a summary of this study.