Record Display for the EPA National Library Catalog

RECORD NUMBER: 44 OF 45

OLS Field Name OLS Field Data
Main Title Two-generation Reproduction Study Via Inhalation (with a Neurotoxicology/pathology Component) in Albino Rats Using Cyclohexanone (Final Report) with Cover Letter.
CORP Author American Biogenics, Inc.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 40-8666137
Stock Number OTS0511206
Additional Subjects Toxicology ; Health effects ; Cyclohexanone ; Reproduction/fertility Effects ; Combined Teratogenicity/reproductive Effects ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 108-94-1
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NTIS  OTS0511206 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 1170p
Abstract
Cyclohexanone was evaluated for reproductive toxicity in CD Sprague-Dawley albino rats (30 rats/sex/generation/concentration group) receiving whole-body exposure to vapor concentrations of 0, 250, 500, or 1000 (F0)/1400 (F1) ppm for 6 hours/day through 2 consecutive generations. F0 adults were exposed 5 days/week for a 10 week pre-mating treatment period. During the 15 day mating period, males and females were exposed 5 and 7 days/week, respectively. Following mating, females were exposed 7 days/week on gestation days 0-20 and on lactation days 5-28. Males continued to be treated 5 days/week post-mating until sacrifice. F1 adults were exposed 5 days/week for 12-15 weeks prior to mating. Exposure of F1 animals during mating, gestation, and lactation was similar to that for the F0 animals. Treatment had no adverse effects with respect to growth or reproductive performance of F0 adults, or F1 fetal or offspring development. High-concentration F1 adults had clinical signs of toxicity. decreased survival rates, male body weights and fertility, and progeny (F2 generation) with decreased survival rates and body weights.