Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Support: An Inhalation Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Female Rats using Multiple Exposure Regimens, with Cover Letter dated 06/01/1998.
CORP Author Dow Corning Corp., Midlands, MI. Health and Environmental Sciences Dept.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1998
Report Number 8EHQ-0698-13585
Stock Number OTS0558459-3
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Octamethylcyclotetrasiloxane ; Reproduction ; Fertility effects ; Combined teratogenicity ; Reproductive effects ; Mammals ; Rats ; Inhalation ; CAS No 556-67-2
Library Call Number Additional Info Location Last
NTIS  OTS0558459-3 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 1112p
In several earlier single generation reproductive toxicity studies, rats were exposed to high concentrations of octamethyleyclotetrasiloxane (OMCTS) for a prolonged premating interval (28 - 70 consecutive days). Exposures continued during the mating period, throughout gestation, and (in some studies) during lactation. In the earlier studies, decreased litter sizes. decreased numbers of uterine implantations. and reduced numbers of corpora lutea were seen; these findings were previously communicated to EPA. This study was conducted to help identify the sensitive interval and reproductive events affected in female rats exposed to OMCTS by whole body vapor inhalation. Female rats were exposed for six hours daily to the test article at different times during their reproductive cycles as noted below. Lapohyster- ectomies were performed on gestation day 20, and corpora lutea and uterine contents were evaluated.