Record Display for the EPA National Library Catalog
RECORD NUMBER: 28 OF 45
|OLS Field Name||OLS Field Data|
|Main Title||Support: An Inhalation Range-Finding Reproductive Toxicity Study of Octamethylcyclotetrasiloxane (D4) in Male Rats with Cover Letter dated 12/03/1997.|
|CORP Author||Dow Corning Corp., Midlands, MI. Health and Environmental Sciences Dept.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Toxic substances ; Octamethylcyclotetrasiloxane ; Reproduction ; Fertility effects ; Combined teratogenicity ; Reproductive effects ; Mammals ; Rats ; Inhalation ; CAS No 556-67-2|
As a supplemental submission to our earlier TSCA Section 8(e) notifications of July 2, 1996 and December 20, 1996, Dow Corning is submitting the final reports for two range-finding inhalation reproductive toxicity studies in which male.rats were exposed to octamethylcyclotetrasitoxane (OMCTS, 94). In the first study, slight decreases (statistically insignificant) in pup viability and statistically significant reductions in FI pup weights were noted in offspring otmale rats from the high exposure group (700 ppm). A second study of similar design but of greater statistical power failed to detect any indication of adverse effects in pups sired by male similarly exposed to OMCTS. We conclude that OMCTS does not cause adverse effects in the offspring of male rats exposed to OMCTS.