Record Display for the EPA National Library Catalog
RECORD NUMBER: 15 OF 45
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Letter from Dupont Chemical to USEPA regarding Embryo-Fetal and Terotogenicity Study of Silane in Rats with Cover Letter and Attachments dated 08/20/1992.|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Toxic substances ; Silane(bis(4- fluropheny))(methyl) (1H-1 ; 2 ; 4-triazol) ; Reproduction ; Fertility effects ; Combined teratogenicity ; Reproductive effects ; Mammals ; Rats ; Oral ; Gavage ; CAS No 85509-19-9|
Rats were dosed at levels of 0, 10, 50, and 250 mg/kg; maternal toxicity and deaths occurred at 250 mg/kg; a significant increase in the incidence of fetuses with cleft palate and with absence of renal papilla was seen at 250 mg/kg. Embryo-fetal toxicity was noted at all levels tested (decreased fetal weight, increased fetal death at 250 mg/kg; and increase incidence of skeletal variations at 10 mg/kg and above).