Record Display for the EPA National Library Catalog

RECORD NUMBER: 15 OF 45

OLS Field Name OLS Field Data
Main Title Initial Submission: Letter from Dupont Chemical to USEPA regarding Embryo-Fetal and Terotogenicity Study of Silane in Rats with Cover Letter and Attachments dated 08/20/1992.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0892-10197
Stock Number OTS0570779
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Silane(bis(4- fluropheny))(methyl) (1H-1 ; 2 ; 4-triazol) ; Reproduction ; Fertility effects ; Combined teratogenicity ; Reproductive effects ; Mammals ; Rats ; Oral ; Gavage ; CAS No 85509-19-9
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS0570779 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 11p
Abstract
Rats were dosed at levels of 0, 10, 50, and 250 mg/kg; maternal toxicity and deaths occurred at 250 mg/kg; a significant increase in the incidence of fetuses with cleft palate and with absence of renal papilla was seen at 250 mg/kg. Embryo-fetal toxicity was noted at all levels tested (decreased fetal weight, increased fetal death at 250 mg/kg; and increase incidence of skeletal variations at 10 mg/kg and above).