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RECORD NUMBER: 6 OF 7

OLS Field Name OLS Field Data
Main Title Glutamate Neurotoxicity in the Developing Rat Cochlea is Antagonized by Kynurenic Acid and MK-801.
Author Janssen, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/024;
Stock Number PB93-141349
Additional Subjects Toxicity ; Cochlea ; Nervous system ; Glutamates ; Kynurenic acid ; Dizocilpine maleate ; Ganglia ; Hair cells ; Afferent neurons ; Rats ; Newborn animals ; Neurotoxins ; Reprints ; Glutamate antagonists ; Ototoxicity
Holdings
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Status
NTIS  PB93-141349 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/12/1993
Collation 8p
Abstract
Glutamate (Glu) is neurotoxic in the neonatal rat cochlea, producing hearing impairment which is largely due to the death of spiral ganglion cells, whereas the receptor hair cells are spared. Dendritic processes of the spiral ganglion are postsynaptic to the primary afferent synapse of the auditory system. The experiments reported here were designed to test whether this apparent excitotoxicity can be blocked by Glu antagonists. (Copyright (c) 1992 Elsevier Science Publishers B.V.)