Record Display for the EPA National Library Catalog

RECORD NUMBER: 13 OF 43

OLS Field Name OLS Field Data
Main Title Drug Transporters [electronic resource] /
Type EBOOK
Author Fromm, Martin F.
Other Authors
Author Title of a Work
Kim, Richard B.
Publisher Springer Berlin Heidelberg,
Year Published 2011
Call Number RM1-950
ISBN 9783642145414
Subjects Medicine. ; Human physiology. ; Drug interactions. ; Toxicology. ; Pharmaceutical technology. ; Clinical medicine. ; Nephrology.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-3-642-14541-4
Collation X, 454 p. online resource.
Notes
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
From the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport. It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.