This document is the second annual report describing progress made by EPA to implement the National Water Program Strategy: Response to Climate Change. It describes activities undertaken by EPA Headquarters program offices and EPA Regions during 2009 to meet the commitments made in the 2008 Strategy. The Strategy was developed by the National Water Program Climate Change Workgroup, which began work in March 2007, and was published in September 2008. It provides an overview of the major impacts of a changing climate on water resources and water programs and describes overall goals for the water program response to climate change. It includes forty-four 'Key Actions' that the Workgroup planned to undertake during 2008 and 2009 that could be initiated with existing resources.