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RECORD NUMBER: 42 OF 53

OLS Field Name OLS Field Data
Main Title Mutagenicity in Salmonella of Hazardous Wastes and Urine from Rats Fed These Wastes.
Author DeMarini, D. M. ; Inmon, J. P. ; Simmons, J. E. ; Berman, E. ; Pasley, T. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/208;
Stock Number PB87-203394
Additional Subjects Industrial wastes ; Mutagens ; Hazardous materials ; Salmonella ; Toxicity ; Exposure ; Rats ; Urine ; Bioassay ; Carcinogens ; Chromosome abnormalities ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-203394 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 29p
Abstract
Fifteen hazardous industrial waste samples were evaluated for mutagenicity in the Salmonella plate-incorporation assay using strains TA98 and TA100 in the presence and absence of Aroclor 1254-induced rat liver S9. Dichloromethane/methanol extracts of the crude wastes also were evalauted. Seven of the crude wastes were mutagenic, but only 2 of the extract of these 7 wastes were mutagenic; extracts of 2 additional wastes also were mutagenic. In addition, 10 of the crude wastes were administered by gavage to F-344 rats, and 24-H urine samples were collected. Of the 10 raw urines evaluated, 3 were mutagenic in strain TA98 in the presence of S9 and B-glucuronidase. To the authors' knowledge, this is the first report of the mutagenicity of urine from rodents exposed to hazardous wastes. Based on the present results, the use of only strain TA98 in the presence of S9 might be adequate for general screening of hazardous wastes or waste extracts for genotoxicity.