Main Title |
Effect of beta-Cyclodextrin on Mucochloric Acid and 3-Chloro-4-(dichloromethyl)-5-hydrox-2(5H)-furanone. |
Author |
Politzer, I. R. ;
Crago, K. T. ;
Benjamin, W. ;
Joseph, J. ;
Amos., K. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Xavier Univ. of Louisiana, New Orleans. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/095; |
Stock Number |
PB91-200295 |
Additional Subjects |
Chemical interactions ;
Cyclodextrins ;
Infrared spectrophotometry ;
Ultraviolet spectrophotometry ;
pH ;
Thin layer chromatography ;
Melting point ;
Fourier analysis ;
Reprints ;
Mucochloric acid
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-200295 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Using a combination of IR and UV techniques, evidence is presented for inclusion complex formation between mucochloric acid and B-cyclodextrin in acidic aqueous solutions. UV evidence supports the conclusion that under these acidic conditions mucochloric acid-B-cyclodextrin complex could be isolated by recrystallization of a 1:1 mole ratio of the above compounds from water at pH2. Solid sample IR (KBr or nujol) showed a carbonyl shift of approximately 20 cm(sup minus 1) when mucochloric acid was compared to the mucochloric acid-B-cyclodextrin complex. No such shift was found upon simply grinding together the above components. Thus the carbonyl shift is ascribed to inclusion complexation of mucochloric acid into the B-cyclodextrin cavity. Melting point and thin layer chromatographic analyses also yield supporting evidence for the formation of solid mucochloric acid-B-cyclodextrin complexes. Pilot studies with 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone (MX), suggest a similar B-cyclodextrin-complex formation in acidic solutions. |