Record Display for the EPA National Library Catalog

RECORD NUMBER: 37 OF 97

OLS Field Name OLS Field Data
Main Title Human Subject Experiments to Estimate Reentry Periods for Monocrotophos-Treated Tobacco.
Author Guthrie, F. E. ; Domanski, J. J. ; Chasson, A. L. ; Bradway, D. E. ; Monroe., R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. ;North Carolina State Univ., Raleigh. Dept. of Entomology.
Year Published 1974
Report Number EPA/600/J-76/060;
Stock Number PB-267 872
Additional Subjects Toxicology ; Pesticides ; Insecticides ; Industrial hygiene ; Personnel ; Exposure ; Erythrocytes ; Cholinesterase inhibitors ; Rainfall ; Deposits ; Reentry ; Intervals ; Humans ; Mice ; Laboratory animals ; Experimental data ; Sampling ; Nitrogen organic compounds ; Phosphorous organic compounds ; Reprints ; Agricultural workers ; Pesticide residues ; Occupational safety and health ; Phosphoric acid/dimethyl ; Crotonamide/hydroxy-N-methyl ; Azodrin
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-267 872 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
Thirteen to fifteen human volunteers worked for eight-hr periods in tobacco fields treated 96, 72, and 48 hr previously with monocrotophos (3-hydroxy-N-methyl-cis-crotonamide dimethyl phosphate). At the 48-hr reentry period, during which time no rainfall occurred, both post-exposure plasma and red blood cell cholinesterase levels of the worker group were depressed from pre-exposure levels although the decline was less than 9% in both cases. Rainfall in excess of one inch fell during the 96- and 72-hr reentry intervals, and no important change in cholinesterase levels was noted. Experiments with mice were in general agreement with the human tests. Dimethyl phosphoric acid in urine of the worker group collected prior to, and three hr after, exposure was unchanged in all cases. Rain appeared to have markedly reduced dislodgable residues.