||Evaluation of Normal and Organophosphate and Carbamate Insecticide Inhibited Blood Cholinesterase Activity Utilizing Dimethylbutylacetate as a Substrate.
Cranmer, M. F. ;
Peoples., A. J. ;
||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Cholinesterase inhibitors ;
Gas chromatography ;
Blood chemical analysis ;
Laboratory animals ;
Blood plasma ;
Acetic acid/butyl-dimethyl ;
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The availability of an extremely sensitive and precise gas chromatogaphic method for the analysis of human blood cholinesterase led to the attempt to apply this method to common laboratory animals where analysis of limited blood samples is important. The results demonstrate DMBA to be acceptable as a cholinesterase substrate both for the determination of normal and inhibited activities in all species except the mouse, where high levels of nonspecific plasma esterases complicate interpretation.