Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evaluation of "CAM-1," : a warning device for organophosphate hazardous material spills /
Author Goodson, Louis H. ; Jacobs., William B.
Other Authors
Author Title of a Work
Jacobs, William B.
Brugger, John E.
CORP Author Midwest Research Inst., Kansas City, Mo.;Industrial Environmental Research Lab., Cincinnati, Ohio.
Publisher U.S. Environmental Protection Agency,
Year Published 1977
Report Number EPA-600/2-77-219; 68-03-0299; PB276647; EPA-68-03-0299; MRI-3820-B
Stock Number PB-276 647
OCLC Number 26140328
Subjects Hazardous substances.
Additional Subjects Hazardous materials ; Organic phosphates ; Detectors ; Carbamates ; Pesticides ; Cholinesterase inhibitors ; Water pollution ; Performance evaluation ; Monitoring ; Sensitivity ; Temperature ; Chemical spills ; Cholinesterase antagonist monitors ; Water pollution detection ; Immobilized enzymes
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJAD  EPA 600/2-77-219 Region 3 Library/Philadelphia, PA 06/02/2000
EJBD ARCHIVE EPA 600-2-77-219 Headquarters Library/Washington,DC 09/28/2009
EJBD  EPA 600-2-77-219 Headquarters Library/Washington,DC 03/18/2014
EKAM  EPA-600/2-77-219 Region 4 Library/Atlanta,GA 08/27/1999
ELBD  EPA 600-2-77-219 AWBERC Library/Cincinnati,OH 06/04/1999
ESAD  EPA 600-2-77-219 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB-276 647 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 44 p.
The Cholinesterase Antagonist Monitor, CAM-1, which uses immobilized cholinesterase on a porous polyurethane pad in an electrochemical cell is able to sense the presence of low concentrations of cholinesterase inhibitors in water on a real time basis. The sensitivity of CAM-1 to organophosphates and carbamates is a function of the affinity of cholinesterase for them; thus its response is greater for those compounds which are more toxic (i.e., the detectable concentrations are inversely proportional to the LD(50)s of these pesticides). Studies were conducted to show the sensitivity of the monitor to 22 organophosphates and 7 carbamate pesticides. Correlation of the sensitivity to chemical structure of the organophosphates shows that introduction of one or two sulfur atoms into the pesticide molecules reduces the sensitivity of the instrument for it. CAM-1 is suited for monitoring of water for the presence of nonreversible cholinesterase inhibitors (i.e., nonreversible in vitro).
"Office of Research and Development." "EPA project officer: John E. Brugger." "EPA-600/2-77-219." "November 1977." "EPA contract no.: 68-03-0299." Includes bibliographical references.