Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Direct Effect of Paraoxon on Erythrocyte Metabolism as Measured by O2 Uptake.
Author Santolucito, J. A. ; Whitcomb., E. R. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1971
Stock Number PB-277 607
Additional Subjects Phosphorus organic compounds ; Cholinesterase inhibitors ; Insecticides ; Pesticides ; Toxicology ; Metabolism ; Exposure ; Erythrocytes ; Rabbits ; Toxicity ; Blood cells ; Oxygen ; Laboratory animals ; Bioassay ; Paraoxon ; Reprints ; Phosphate/O-O-diethyl-O-nitrophenyl ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-277 607 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1p
In studying the effects of anticholinesterase compounds, the blood has been considered primarily as an index of exposure; however, there are reports in the literature which suggest that anticholinesterase compounds may have an effect on the erythrocyte itself. This study was undertaken to measure the metabolic O2 uptake of rabbit erythrocytes and the rate of erythrocyte removal from general circulation after exposure to paraoxon. There was no apparent acceleration of removal rate of the paraoxon treated erythrocyte in the general circulation. These results suggested that paraoxon acted on -SH groups in blocking O2 uptake.