||Effect of Chloroquin on Hepatic Microsomal Enzyme of the Squirrel Monkey.
Cranmer, M. ;
Peoples., A. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Physiological effects ;
Laboratory animals ;
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The present work was done to examine the possible effect on the hepatic microsomal enzymes and P-450 content of squirrel monkeys treated with chloroquin. Chloroquin was found to stimulate the o-demethylation of p-nitroanisole and the oxidative hydrolysis of EPN but not to increase hepatic P-450. A 30-day 10 mg kg/day chloroquin pretreatment to 4 adult male squirrel monkeys blocked the stimulation of P-450 by a 3 day 5 mg/kg administration of p,p'-DDT and decreased the stimulation of hepatic microsomal enzymes by p,p'-DDT.