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RECORD NUMBER: 34 OF 267

OLS Field Name OLS Field Data
Main Title Carcinogenicity of Chloroform in Drinking Water to Male Osborne-Mendel Rats and Female B6C3F1 Mice.
Author Jorgenson, T. A. ; Meierhenry, E. F. ; Rushbrook, C. J. ; Bull, R. J. ; Robinson, M. ;
CORP Author SRI International, Menlo Park, CA.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1985
Report Number EPA-68-03-2616; EPA/600/J-85/221;
Stock Number PB86-118734
Additional Subjects Chloroform ; Potable water ; Toxicology ; Rats ; Mice ; Laboratory animals ; Reprints ; Carcinogenesis
Holdings
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Status
NTIS  PB86-118734 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 11p
Abstract
The carcinogenic activity of chloroform administered at 0, 200, 400, 900, and 1800 mg/liter in drinking water was studied in male Osborne-Mendel rats and female B6C3F1 mice. A second control group was included in the study and was restricted to the water consumption of the high-dose group. Animals were maintaind on study for 104 weeks. Group sizes were adjusted at low doses such that a detectable tumor response would result at the lowest dose if there was a linear relationship with dose, and the higher doses produced responses similar to previous carcinogenesis bioassays of chloroform. The primary finding was that chloroform increased the yield of renal tubular adenomas and adenocarcinomas in male rats in a dose-related manner. For the high-dose group, which corresponded to a time-weighted average dose of 160 mg/kg per day for 104 weeks, there was a 14% incidence of renal tubular adenomas and adenocarcinomas, vs 1% in the control group. This compares to a 24% incidence observed when 180 mg/kg per day of chloroform was administered for 78 weeks in earlier studies.