Record Display for the EPA National Library Catalog

RECORD NUMBER: 40 OF 40

OLS Field Name OLS Field Data
Main Title Toxicity of Chlorine Dioxide in Drinking Water.
Author Abdel-Rahman, M. S. ; Couri, D. ; Bull, R. J. ;
CORP Author New Jersey Medical School, Newark. Dept. of Pharmacology. ;Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-807473; EPA/600/J-84/175;
Stock Number PB85-146736
Additional Subjects Chlorine oxides ; Toxicity ; Water treatment ; Disinfection ; Rodents ; Blood cells ; Liver ; Kidney ; Weight(Mass) ; Intestines ; Reprints ; Chlorine dioxide ; Drinking water
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-146736 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Chlorine dioxide (ClO2) is currently being considered as an alternate to chlorine as a disinfectant for public water supplies. Studies were conducted to determine the toxicity of ClO2 (0, 1, 10, 100, 1000 mg/L) and its metabolites, ClO2(-1) and ClO3(-1) (10, 100 mg/L) in drinking water in rats. After 9 months treatment the osmotic fragility of the red blood cells was decreased in all treatment groups, while a decreased blood glutathione was only observed in the metabolite groups. At 2, 4, and 6 months no significant hematologic changes were noted in treated rats compared to control. However, after 9 months RBC counts, hematocrit, and hemoglobin were decreased in all treatment groups. ClO2, ClO2(-1), and ClO3(-1) administered chronically in drinking water for 3 months inhibited the incorporation of (3)H-thymidine into nuclei of rat tests. The treatment with Cl compounds decreased rat body weight in all groups after 10 and 11 months treatment.