||Association between birth defects and exposure to ambient vinyl chloride /
Theriault, Gilles P. ;
Iturra, Hilda ;
||Laval Univ., Quebec.;Health Effects Research Lab., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Vinyl chloride--Toxicology. ;
Vinyl chloride--Physiological effect. ;
Teratogenic agents. ;
Vinyl chloride ;
Congenital abnormalities ;
Air pollution ;
Chlorine organic compounds ;
Seasonal variations ;
Foreign technology ;
Birth defects ;
Toxic substances ;
Air pollution effects(Humans)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||106 pages : illustrations ; 28 cm
To better define the association between exposure to vinyl chloride monomer (VCM) and the occurrence of birth defects, this epidemiological study was made in Shawinigan, Quebec, Canada, where a vinyl chloride polymerization plant has operated since 1943. Birth-defect rates in Shawinigan during the last 15 years were compared with rates in three other communities, and seasonal and spatial variations in Shawinigan's birth-defect rate were correlated with estimated VCM concentrations in the environment. Shawinigan had an excess of birth defects which fluctuated seasonally in a way that could correspond to changes in VCM concentration in the environment. Mothers who gave birth to malformed children were younger on average in Shawinigan than in the comparison communities. However, there was no excess of stillbirths in Shawinigan, the excess of birth defects involved most systems, and variation in birth-defect rates among school districts could not be accounted for by estimates of VCM in the atmosphere. The occupational and residential histories of parents who gave birth to malformed infants were compared with those of parents of normal infants. The two groups did not differ in occupational exposure or closeness of residence to the vinyl chloride polymerization plant.
Caption title. "August 1981." "EPA-600/1-81-057." Microfiche.