Record Display for the EPA National Library Catalog

RECORD NUMBER: 29 OF 84

OLS Field Name OLS Field Data
Main Title Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man.
Author Lubbers, Judith R. ; Chauan, Sudha ; Bianchine, Joseph R. ;
CORP Author Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-805643; EPA-600/J-81-367;
Stock Number PB83-187856
Additional Subjects Disinfectants ; Chlorine dioxide ; Chlorite ; Chlorate ; Toxicology ; Humans ; Safety ; Tolerance(Physiology) ; Physiological effects ; Reprints ; Water pollution effects(Humans)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-187856 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising does tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects.