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RECORD NUMBER: 7 OF 42

OLS Field Name OLS Field Data
Main Title Carcinogenicity assessment of chlordane and heptachlor/heptachlor epoxide.
Author Cavender, F. L. ; Cook, B. T. ; Page, N. P. ; Cogliano, V. J. ; Koppikar, A. M.
CORP Author United States. Environmental Protection Agency. Carcinogen Assessment Group.
Publisher Carcinogen Assessment Group, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1986
Report Number EPA/600/6-87-004
Stock Number PB87-208757
OCLC Number 16388648
Subjects Chlordan--Carcinogenicity. ; Heptachlor--Carcinogenicity.
Additional Subjects Carcinogenesis ; Chlordane ; Malignant neoplasms ; Pesticides ; Toxicity ; Bioassay ; Laboratory animals ; Liver ; Exposure ; Epidemiology ; Chlorinated hydrocarbons ; Toxic substances ; Carcinogenesis ; Cancer ; CAS 57-74-9 ; CAS 76-44-8 ; CAS 1024-57-3 ; Heptachlor epoxide ; Heptachlor ; Occupational safety and health
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30000Y2C.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EHAM  RC268.64.C37C3 1986 Region 1 Library/Boston,MA 04/29/2016
EIAD  EPA/600/6-87-004 Region 2 Library/New York,NY 04/28/2006 DISPERSAL
EJAD  EPA 600/6-87-004 Region 3 Library/Philadelphia, PA 12/24/1992
EJBD ARCHIVE EPA 600-6-87-004 Headquarters Library/Washington,DC 04/04/2016
EJED  EPA 600/6-87-004 OCSPP Chemical Library/Washington,DC 01/01/1988
EKAM  EPA/600/6-87/004 Region 4 Library/Atlanta,GA 06/10/1994
EKBD  EPA-600/6-87-004 Research Triangle Park Library/RTP, NC 01/01/1988
EKCD  EPA/600/6-87/004 NHEERL/GED Library/Gulf Breeze,FL 07/25/2018
ELDD  EPA/600/6-87-004 NHEERL/MED Library/Duluth,MN 01/30/1998
EOBD  EPA 600-6-87-004 NEIC Library/Denver,CO 11/19/1999
ERAD  EPA 600/6-87-004 Region 9 Library/San Francisco,CA 09/06/2013
ESAD  EPA 600-6-87-004 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB87-208757 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 1 volume (various pagings) : illustrations ; 28 cm
Abstract
Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before 1985. Case reports and epidemiologic studies of pesticide applicators and pesticide manufacturing workers are reviewed, but because of methodologic limitations, these studies establish neither a positive nor a negative association between cancer and chlordane or heptachlor/heptachlor epoxide exposure. A number of independent studies of laboratory animals, however, demonstrates that chlordane and heptachlor/heptachlor epoxide cause liver cancer in mice and rats. Based on the accumulated evidence, chlordane and heptachlor/heptachlor epoxide are classified as probable human carcinogens, Group B2 using EPA's Guidelines for Carcinogen Risk Assessment. The carcinogenic potency of chlordane and heptachlor/heptachlor epoxide is estimated by fitting mathematical models to the laboratory animal data. These estimates indicate that chlordane and heptachlor/heptachlor epoxide are rather potent carcinogens, ranking in the second quartile of potential carcinogens evaluated by EPA's Carcinogen Assessment Group. A separate mutagenicity assessment of chlordane and heptachlor/heptachlor epoxide is attached as an appendix to the report. The report also includes an extensive list of references pertinent to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide.
Notes
Distributed to depository libraries in microfiche. "December 1986." Includes bibliographical references (pages 7-1-7-10). "EPA-600/6-87/004."