Record Display for the EPA National Library Catalog
RECORD NUMBER: 11 OF 12
|OLS Field Name||OLS Field Data|
|Main Title||Toxicological review of chloral hydrate (CAS No. 302-17-0) : in support of summary information on the Integrated Risk Information System (IRIS) /|
|CORP Author||Environmental Protection Agency, Washington, DC.|
|Publisher||U.S. Environmental Protection Agency, National Center for Environmental Assessment,|
|Subjects||Hazardous substances--Health aspects--Reporting.|
|Additional Subjects||Toxicity ; Chloral hydrate ; Environmental exposure ; Health hazards ; Dose-response relationships ; Hazardous substances ; Carcinogens ; Chemical properties ; Physical properties ; Dermal absorption ; Carcinogenicity tests ; Toxicology ; Inhalation ; Oral dosage ; Dose rate ; Epidemiology ; Bioassay ; Chronic disease ; Chronic exposure ; Reproduction(Biology) ; Factor analysis ; CAS No 302-17-0 ; IRIS(Integrated Risk Information System) ; Taxicokinetics|
|Collation||70 pages ; 28 cm|
This document presents background and justification for the hazard and dose-response assessment summaries in EPA's Integrated Risk Information System (IRIS). IRIS summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC), and a carcinogenicity assessment. The RfD and RfC provide quantitative information for noncancer dose-response assessments. The RfD is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis but may not exist for other toxic effects such as some carcinogenic responses. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious noncancer effects during a lifetime. The inhalation RfC is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). It is generally expressed in units of mg/m 3.
"August 2000." "EPA/635/R-00/006." Includes bibliographical references. "PB2001-100094." Microfiche.