Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 71

OLS Field Name OLS Field Data
Main Title Effect of lead on gamma amino butyric acid synthesis /
Author Moses, Henry Archie.
CORP Author Meharry Medical Coll., Nashville, Tenn. Dept. of Biochemistry and Nutrition.;Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA/600/1-78/009; EPA-R-802370
Stock Number PB-277 022
OCLC Number 42838641
Subjects Brain chemistry--Research. ; Lead--Toxicology.
Additional Subjects Lead(Metal) ; Enzyme inhibitors ; Toxicology ; Biosynthesis ; Brain ; Rats ; Experimental data ; Ingestion(Biology) ; Bioassay ; Dosage ; Toxicity ; Lead poisoning ; Toxic diseases ; Tissues(Biology) ; Absorption(Biology) ; Experimental data ; Butyric acid/4-amino ; Neurochemistry ; Decarboxylase/glutamic acid
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013FEH.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-78-009 Region 3 Library/Philadelphia, PA 01/14/2000
EJBD ARCHIVE EPA 600-1-78-009 Headquarters Library/Washington,DC 04/28/2014
EJBD  EPA 600-1-78-009 c.1 Headquarters Library/Washington,DC 06/09/2014
EKAM  EPA 600/1-78/009 Region 4 Library/Atlanta,GA 11/19/1999
EKBD  EPA-600/1-78-009 Research Triangle Park Library/RTP, NC 02/23/2000
NTIS  PB-277 022 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation ix, 28 p. ; 28 cm.
Abstract
The project studies the inhibitory effect of lead on the enzymatic activity of brain glutamic amino acid decarboxylase (GADC). The enzyme is responsible for the catalytic formation of gamma amino butyric acid (GABA) inhibitory neurons which is believed to be involved with the transmission of inhibitory impulses in the brain. Lead nitrate solution was available to Sprague-Dawley female rats ad libitum and the quantity of lead ingested was determined by the volumes consumed. During the course of these experiments, animals were examined for weight loss, activity, and excitability and other behavioral manifestations of lead toxicity. At autopsy, the tissues selected for lead determinations were brain, liver, bone (femur). In another series of experiments GADC was isolated from fresh bovine brain tissue, and in vitro studies were performed to determine the nature of lead inhibition of the enzyme. Subsequently, Se and Cd inhibition of the enzyme were studied and compared to lead inhibition. The activity of the enzyme GADC in brain tissue homogenates of rats drinking lead nitrate solutions was less than the activity determined in control rats. When the inhibiting effect of Pb, Cd, and Se on GADC activity were compared, Pb proved to be the most potent inhibitor, while Cd showed less inhibition, showed no inhibition of enzyme activity.
Notes
"EPA-600/1-78-009". EPA grant no. R-802370; EPA project officer: Larry L. Hall. Bibliography: p. 14.