Main Title |
Evaluation of "CAM-1," : a warning device for organophosphate hazardous material spills / |
Author |
Goodson, Louis H. ;
Jacobs., William B.
|
Other Authors |
|
CORP Author |
Midwest Research Inst., Kansas City, Mo.;Industrial Environmental Research Lab., Cincinnati, Ohio. |
Publisher |
U.S. Environmental Protection Agency, |
Year Published |
1977 |
Report Number |
EPA-600/2-77-219; 68-03-0299; PB276647; EPA-68-03-0299; MRI-3820-B |
Stock Number |
PB-276 647 |
OCLC Number |
26140328 |
Subjects |
Hazardous substances
|
Additional Subjects |
Hazardous materials ;
Organic phosphates ;
Detectors ;
Carbamates ;
Pesticides ;
Cholinesterase inhibitors ;
Water pollution ;
Performance evaluation ;
Monitoring ;
Sensitivity ;
Temperature ;
Chemical spills ;
Cholinesterase antagonist monitors ;
Water pollution detection ;
Immobilized enzymes
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-2-77-219 |
|
Headquarters Library/Washington,DC |
03/18/2014 |
ELBD ARCHIVE |
EPA 600-2-77-219 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-2-77-219 |
|
AWBERC Library/Cincinnati,OH |
06/04/1999 |
ESAD |
EPA 600-2-77-219 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB-276 647 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
44 p. |
Abstract |
The Cholinesterase Antagonist Monitor, CAM-1, which uses immobilized cholinesterase on a porous polyurethane pad in an electrochemical cell is able to sense the presence of low concentrations of cholinesterase inhibitors in water on a real time basis. The sensitivity of CAM-1 to organophosphates and carbamates is a function of the affinity of cholinesterase for them; thus its response is greater for those compounds which are more toxic (i.e., the detectable concentrations are inversely proportional to the LD(50)s of these pesticides). Studies were conducted to show the sensitivity of the monitor to 22 organophosphates and 7 carbamate pesticides. Correlation of the sensitivity to chemical structure of the organophosphates shows that introduction of one or two sulfur atoms into the pesticide molecules reduces the sensitivity of the instrument for it. CAM-1 is suited for monitoring of water for the presence of nonreversible cholinesterase inhibitors (i.e., nonreversible in vitro). |
Notes |
"Office of Research and Development." "EPA project officer: John E. Brugger." "EPA-600/2-77-219." "November 1977." "EPA contract no.: 68-03-0299." Includes bibliographical references. |